TABLE 4.
Serum antibody response in volunteers given V. cholerae El Tor Ogawa strain 638 orally
| Immune response | Volunteers given:
|
|||
|---|---|---|---|---|
| High dose | Medium dose | Low dose | Placebo | |
| Ogawa vibriocidal antibodiesa | ||||
| No. seroconverted (fourfold) (%) | 24/29 (82) | 5/6 (83) | 5/7 (71) | 0/14 (0) |
| GMTb (range) | ||||
| Preinoculation | 47 (0–160) | 32 (0–40) | 33 (0–40) | 37 (0–320) |
| Postinoculation peak (14 days) | 873 (0–20,480) | 639 (0–2,560) | 389 (40–2,560) | 46 (0–320) |
| No. of responders with titers ≥ 1,024/total no. | 10/24 | 4/5 | 4/5 | 0 |
| Anti-Ogawa LPS IgGc | ||||
| No. seroconverted (twofold) (%) | 23/29 (79) | 4/6 (67) | 3/7 (43) | 1/14 (7) |
| No. seroconverted (fourfold) (%) | 21/29 (71) | 4/6 (67) | 3/7 (43) | 1/14 (7) |
| Log reciprocal titerd ± SDe | ||||
| Preinoculation | 0.12 ± 0.25 | 0.12 ± 0.29 | 0 | 0.03 ± 0.12 |
| Postinoculation peak (14 days) | 1.86 ± 1.12 | 1.56 ± 1.49 | 1.07 ± 1.36 | 0.19 ± 0.57 |
| Anti-Ogawa LPS IgAc | ||||
| No. seroconverted (twofold) (%) | 26/29 (90) | 6/6 (100) | 5/7 (71) | 0/14 (0) |
| No. seroconverted (fourfold) (%) | 24/29 (83) | 6/6 (100) | 4/7 (57) | 0/14 (0) |
| Log reciprocal titer ± SD | ||||
| Preinoculation | 0.1 ± 0.37 | 0 | 0.27 ± 0.37 | 0.13 ± 0.39 |
| Postinoculation peak (14 days) | 2.43 ± 1.0 | 2.68 ± 0.48 | 1.96 ± 1.25 | 0.19 ± 0.53 |
a
Number of volunteers with fourfold increase in titer/total number of volunteers. The seroconversion rate is shown as a percentage in the parentheses.
b
GMT, geometric mean titer.
c
Number of volunteers with two- or fourfold increase in titer/total number of volunteers.
d
Logarithm of the reciprocal arithmetic mean titer.
e
SD, standard deviation of the mean.