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Recombinant Topo II inhibitory activities of compounds 6, 7a, 7b, 8a, 9a, and 10c at 100, 10, 1, 0.1 µM. Lane P: pBR322 DNA only; lane N: pBR322 DNA + Topo II; lanes (6, 7a, 7 b, 8a, 9a and 10c): pBR322 DNA + Topo II + compounds 6, 7a, 7 b, 8a, 9a and 10c.
