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. 2022 Nov 4;130(11):117003. doi: 10.1289/EHP11360

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EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted.

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Figures 2A to 2H are eight bar graphs, plotting Cer (Normalized L C-M S Area), ranging from 0.0 to 1.5 in increments of 0.5; S M (Normalized L C-M S Area), ranging from 0 to 8 in increments of 2; L P C (Normalized L C-M S Area), ranging from 0 to 20 in increments of 5; L P E (Normalized L C-M S Area), ranging from 0.0 to 2.0 in increments of 0.5; P C (Normalized L C-M S Area), ranging from 0 to 30 in increments of 10; P E (Normalized L C-M S Area), ranging from 0 to 800 in increments of 200; cholesterol ester (Normalized L C-M S Area), ranging from 0.0 to 0.4 in increments of 0.1; and T A G (Normalized L C-M S Area), ranging from 0 to 800 in increments of 200 (y-axis) across uppercase c plus vehicle, uppercase c plus P F O S, uppercase i plus vehicle, uppercase i plus P F O S, uppercase p plus vehicle, and uppercase p plus P F O S (x-axis). — Liver lipid profiles in mice exposed to PFOS and fed with diets supplemented with different fibers (C: cellulose as control, I: inulin, P: pectin). Lipids including sphingolipids (Cer, A; SM, B), lysophospholipids (LPC, C; LPE, D), phospholipids (PC, E; PE, F), cholesterol ester (ChE, G), and a neutral lipid (TAG, H) were analyzed using UHPLC-Q exactive MS. The normalized peak areas of lipid species in each lipid class are summarized. Bars represent $means \pm SEMs$ of 6–8 mice in each group. Data were compared using two-way ANOVA and Tukey’s post hoc test for multiple comparisons, * $lowercase italic p less than 0.05$ ; ** $lowercase italic p less than 0.01$ ; *** $lowercase italic p less than 0.001$ ; and **** $lowercase italic p less than 0.0001$ . Detailed lipidomic data are listed in Excel Table S12. Note: ANOVA, analysis of variance; Cer, ceramide; LC-MS, liquid chromatography-mass spectrometry; LPC, lysophosphatidylcholine; LPE, lysophosphatidylethanolamine; PC, phosphatidylcholine; PE, phosphatidylethanolamine; PFOS, perfluorooctane sulfonate; SEM, standard error of the mean; SM, sphingomyelin; UHPLC-Q exactive MS, ultra-high-performance liquid chromatography coupled with quadrupole-exactive mass spectrometer; TAG, triacylglycerol.

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