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. 2022 Nov 4;130(11):117003. doi: 10.1289/EHP11360

Figure 3.

Figure 3 is a set a six bar graphs, plotting 16 to 0 Ceramides, ranging from 0.00 to 0.25 in increments of 0.05; 18 to 0 Ceramides, ranging from 0.00 to 0.06 in increments of 0.02; 20 to 0 Ceramides, ranging from 0.00 to 0.04 in increments of 0.01; 22 to 0 Ceramides, ranging from 0.00 to 0.15 in increments of 0.05; 24 to 0 Ceramides, ranging from 0.00 to 0.15 in increments of 0.05; 24 is to 1 Ceramides, ranging from 0.0 to 0.6 in increments of 0.2 (y-axis) across uppercase c plus vehicle, uppercase c plus P F O S, uppercase i plus vehicle, uppercase i plus P F O S, uppercase p plus vehicle, and uppercase p plus P F O S (x-axis).

Liver ceramide levels in mice exposed to PFOS and fed diets supplemented with different fibers (C: cellulose as control, I: inulin, P: pectin). Ceramides were analyzed using UHPLC-Q Exactive MS. Bars represent means±SEMs of 6–8 mice in each group. Data were compared using two-way ANOVA and Tukey test for multiple comparisons, *p<0.05; **p<0.01; ***p<0.001; and ****p<0.0001. Detailed ceramide data are listed in Excel Table S12. Note: ANOVA, analysis of variance; PFOS, perfluorooctane sulfonate; SEM, standard error of the mean; UHPLC-Q exactive MS, ultra-high-performance liquid chromatography coupled with quadrupole-exactive mass spectrometer.