Table 1.

Metabolomic analysis of liver samples from mice exposed to PFOS and fed with diets supplemented with cellulose (control), inulin, or pectin.

Metabolite	Category	MW	Rt (min)	Fold difference: PFOS vs. vehicle
				Cellulose	Inulin	Pectin
Glutarylcarnitine	Short-chain acylcarnitine	275.136	5.7	158.0	18.4	45.9
Malonylcarnitine	Short-chain acylcarnitine	247.105	7.1	3.4	3.5	2.9
Pimelylcarnitine	Short-chain acylcarnitine	303.168	2.4	0.3	0.3	0.3
Inosine-5′-monophosphate	Nucleotide metabolism	348.046	9.7	7.2	6.1	45.1
Inositol cyclic phosphate	Nucleotide metabolism	242.019	10.9	3.2	2.3	3.3
Uridine monophosphate	Nucleotide metabolism	324.035	9.2	2.2	2.9	5.2
Uridine diphosphate	Nucleotide metabolism	404.001	10.4	4.5	2.8	5.7
UDP-$N$-acetylglucosamine	Nucleotide metabolism	607.080	9.3	2.8	2.6	3.4
Cytidine	Nucleotide metabolism	243.085	6.4	0.3	0.4	0.4
Cytosine	Nucleotide metabolism	111.043	6.4	0.3	0.4	0.4
Isocytosine	Nucleotide metabolism	111.043	5.2	0.3	0.4	0.4
Nicotinic acid	Nucleotide metabolism	123.032	2.7	3.0	2.6	2.4
Acetylarginine	Arginine metabolism	216.122	9.0	5.2	4.3	2.2
Aceglutamide	Glutamine metabolism	188.079	4.7	2.4	2.9	2.3
$S$-methylglutathione	Glutathione metabolism	321.099	7.0	3.6	2.9	2.7
$N$-acetyl-aminoadipic acid	Lysine metabolism	203.079	9.3	3.0	2.4	3.0
Aminobenzoic acid	Tryptophan metabolism	137.048	9.3	3.6	3.0	3.9
Aminobutyric acid	Alanine metabolism	103.064	7.8	0.4	0.3	0.3
Dihydroxyphenylacetic acid	Amine metabolism	168.042	10.9	2.7	2.3	3.2
Glycine hydroxyproline dipeptide (Gly-Hyp)	Dipeptide	188.080	2.4	2.6	2.4	2.2
Gly-Lys	Dipeptide	203.127	6.3	0.2	0.2	0.2
Hypotaurocyamine	Other	151.041	9.7	0.5	0.4	0.2
Benzoxazolone	Other	135.032	3.8	0.4	0.5	0.4

Note: Core metabolite differences in response to PFOS exposure across all three dietary groups are listed ($n=6–8/\text{group}$). The fold difference data were obtained from volcano plot results as determined by using MetaboAnalyst (version 5.0). Detailed metabolomic data are listed in Excel Table S5. Lys, lysine; MW, molecular weight; PFOS, perfluorooctane sulfonate; Rt, retention time; UDP, uridine diphosphate.