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. 2022 Nov 3;13(1):1985–2011. doi: 10.1080/21505594.2022.2141987

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Histopathology of leprosy. (a) TT is characterized by granulomas with lymphocyte infiltration. These are multiple, well-formed granulomas with multinuclear Langhans giant cells. Erosion of the basal layer of epidermis is observed, with lymphocytes (→). (HE stain, 40×). (b) in BT lesions a granulomatous appearance can be observed (→), similar to TT lesions, with the presence of a grenz zone. Lymphocytic infiltration is less than in TT. (HE stain, 40×). (c) in BL cases, lymphocytic infiltration and histiocytes (→) with granular to foamy cytoplasm are observed. (HE stain, 40×). (d) LL is characterized by foamy histiocytes with a grenz zone below the epidermis. (→) (HE stain, 40×) (A) the slit skin smear test shows the acid fast bacilli. (→) (Ziehl- Neelsen stain, 1000×). (B) a large number of bacilli are observed within foamy histiocytes with LL lesions. (→) (Ziehl- Neelsen stain, Wade-Fite, 400×). Photomicrographs are courtesy of Dr. Norihisa Ishii, National Sanatorium Tama Zenshoen.