Table 1.
Parameters of thrombin generation in PRP from patients with mild and moderate hemophilia A
| Patients with mild hemophilia A (n = 10) | Patients with moderate hemophilia A (n = 6) | |||||
|---|---|---|---|---|---|---|
| PRP alone | PRP + irrelevant IgG | PRP + anti-PN-1 | PRP alone | PRP + irrelevant IgG | PRP + anti-PN-1 | |
| Lag time, min | 10.32 ± 2.92 | 10.33 ± 2.96 | 10.32 ± 3.02 | 11.98 ± 1.70 | 12.09 ± 1.70 | 11.89 ± 1.83 |
| Peak, nM | 87.68 ± 32.70 | 87.16 ± 35.19 | 110.8 ± 42.10* | 75.05 ± 21.33 | 71.88 ± 24.37 | 96.25 ± 32.91† |
| TTP, min | 23.23 ± 5.09 | 23.34 ± 5.07 | 21.55 ± 4.68‡ | 25.41 ± 4.63 | 25.73 ± 4.82 | 22.92 ± 4.30† |
| ETP, nM⋅min | 1485 ± 381.0 | 1474 ± 382.2 | 1442 ± 374.2 | 1341 ± 448.0 | 1288 ± 452.6 | 1299 ± 410.6 |
| Velocity, nM/min | 7.26 ± 3.63 | 7.07 ± 3.64 | 10.99 ± 6.63* | 5.77 ± 2.24 | 5.56 ± 2.67 | 9.19 ± 4.65† |
Means ± SD. A nonparametric 1-way ANOVA test followed by a multiple comparison test was used.
*
P < .01.
†
P < .05.
‡
P < .001 vs PRP + irrelevant IgG.