Table 2.

Parameters of thrombin generation in PRP from patients with mild and moderate hemophilia B

	Patients with mild hemophilia B (n = 5)			Patients with moderate hemophilia B (n = 3)
	PRP alone	PRP + irrelevant IgG	PRP + anti-PN-1	PRP alone	PRP + irrelevant IgG	PRP + anti-PN-1
Lag time, min	11.53 ± 1.55	11.33 ± 1.76	11.41 ± 1.87	14.62 ± 2.09	15.29 ± 3.57	15.74 ± 3.90
Peak, nM	75.28 ± 11.50	77.49 ± 12.65	97.73 ± 16.28*	29.92 ± 6.12	31.07 ± 5.41	43.09 ± 3.31
TTP, min	22.31 ± 3.76	21.88 ± 3.91	20.69 ± 2.78	27.11 ± 2.93	30.01 ± 6.32	29.73 ± 3.53
ETP, nM⋅min	1368 ± 411.2	1395 ± 374.4	1292 ± 303.4	775,6 ± 173.0	1013 ± 491.1	813.1 ± 264.9
Velocity, nM/min	7.44 ± 1.92	7.51 ± 1.98	10.60 ± 1.73*	2,47 ± 0.80	2.33 ± 0.85	2.80 ± 0.44

Means ± SD. A nonparametric 1-way ANOVA test followed by a multiple comparison test was used.

^* P < .05 vs PRP + irrelevant IgG.