Table 3.

Parameters of thrombin generation in PRP from patients with severe hemophilia A and B without collagen-induced platelet activation

	PRP alone	PRP + irrelevant IgG	PRP + anti-PN-1
Patients with severe hemophilia A (n = 8)
Lag time, min	12.82 ± 6.87	13.05 ± 7.03	13.40 ± 7.36
Peak, nM	20.21 ± 12.18	19.19 ± 10.44	20.96 ± 11.76
TTP, min	40.40 ± 22.26	41.45 ± 22.95	39.15 ± 23.94
ETP, nM⋅min	230.9 ± 336.8	235.9 ± 323.6	360.5 ± 383.5
Velocity, nM/min	0.74 ± 0.51	0.67 ± 0.45	0.87 ± 0.61
Patients with severe hemophilia B (n = 4)
Lag time, min	8.21 ± 6.0	8.90 ± 3.77	8.44 ± 3.73
Peak, nM	9.03 ± 7.07	9.19 ± 6.42	11.97 ± 6.24
TTP, min	24.25 ± 7.0	24.21 ± 6.39	28.94 ± 2.45
ETP, nM⋅min	254.9 ± 198.9	272.3 ± 149.3	398.2 ± 140.8
Velocity, nM/min	0.51 ± 0.43	0.59 ± 0.36	0.65 ± 0.48