Table 4.

Parameters of thrombin generation in PRP from patients with severe hemophilia A and B with collagen-induced platelet activation

	PRP alone	PRP + irrelevant IgG	PRP + anti-PN-1
Patients with severe hemophilia A (n = 6)
Lag time, min	12.48 ± 4.61	12.14 ± 4.72	11.23 ± 4.70
Peak, nM	22.59 ± 11.66	23.59 ± 11.65	31.49 ± 16.20*
TTP, min	40.30 ± 5.67	39.90 ± 5.49	34.94 ± 6.31*
ETP, nM⋅min	1060 ± 587.0	1103 ± 579.0	1172 ± 581.9
Velocity, nM/min	0.81 ± 0.39	0.88 ± 0.41	1.39 ± 0.81*
Patients with severe hemophilia B (n =3)
Lag time, min	8.85 ± 1.08	8.39 ± 1.08	8.30 ± 1.75
Peak, nM	19.56 ± 6.64	19.56 ± 6.11	38.95 ± 10.62
TTP, min	29.59 ± 0.92	28.30 ± 1.45	26.04 ± 2.93*
ETP, nM⋅min	1046 ± 243.2	926.1 ± 300.3	1429 ± 194.0*
Velocity, nM/min	1.05 ± 0.31	0.99 ± 0.32	2.23 ± 0.78

Means ± SD. A nonparametric 1-way ANOVA test followed by a multiple comparison test was used.

^*P < .05 vs PRP + irrelevant IgG.