. 2019 Aug 5;134(19):1632–1644. doi: 10.1182/blood.2019000281

Table 6.

Parameters of thrombin generation in murine PRP after collagen-induced platelet activation

	WT (n = 22)^*	PN-1^−/− (n = 12)^*	F8^−/− (n = 13)^*	F8^−/−/PN-1^−/− (n = 15)^*	F8^−/− (n = 10)
	WT (n = 22)^*	PN-1^−/− (n = 12)^*	F8^−/− (n = 13)^*	F8^−/−/PN-1^−/− (n = 15)^*	PRP alone^†	PRP + irrelevant IgG^†	PRP + anti-PN-1^†
Lag time, min	4.92 ± 1.30	5.14 ± 0.83	3.57 ± 0.75	3.63 ± 0.88	3.36 ± 0.74	4.67 ± 3.57	3.67 ± 0.55
Peak, nM	27.06 ± 7.43	27.41 ± 9.81	5.50 ± 2.65	8.50 ± 3.74^‡	7.18 ± 6.28	7.16 ± 6.29	9.73 ± 8.05^¶
TTP, min	9.57 ± 1.73	10.39 ± 1.87	10.55 ± 1.53	10.81 ± 1.11	9.12 ± 1.74	9.93 ± 2.84	8.36 ± 0.94
ETP, nM.min	373.8 ± 134.4	361.8 ± 136.0	65.47 ± 28.04	114.3 ± 61.90^‡	88.45 ± 74.25	79.43 ± 65.34	87.30 ± 66.90
Velocity, nM/min	5.89 ± 2.08	5.78 ± 3.17	0.99 ± 0.63	1.05 ± 0.61	1.37 ± 1.38	1.41 ± 1.37	2.3 ± 1.98^¶

Thrombin generation was triggered by TF and collagen. Means ± SD.

A Mann-Whitney test was used here.

^†

A nonparametric 1-way ANOVA test followed by a multiple comparison test was used here.

^‡

P < .05 vs F8^−/− mice

^¶

P < .01 vs PRP + irrelevant IgG.