Fig. 2.

Robust IgG production after JYNNEOS vaccination. D0, D42 and D730 serum specimens from participants were serially diluted and tested by ELISA to determine VACV-specific IgG endpoint titers (EPTs). IgG EPTs shown for Naïve (A) and Prior Vaccination (B) groups. Statistical significance determined using one-way ANOVA with post-hoc Tukey’s multiple comparisons test. P-values represented as asterisks. *p < 0.05, **p < 0.01 and ****p < 0.0001, ns: not significant. C) Fold change in VACV-specific IgG EPTs between D0 and D42 (left) and D0 and D730 (right) for Naïve and Prior Vaccination groups. Graphs show individual data points and mean values +/- SEM. Median values tabulated below respective graphs.