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. 2022 Nov 5;4:100125. doi: 10.1016/j.snr.2022.100125

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© 2022 The Authors. Published by Elsevier B.V.

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Fig. 13 — Design of Mini-MG 1.0 in complex with its mismatched analyte (NC-45A) and matched analyte (NC-45). The design of Mini-MG 1.0, show left, consist of a strong analyte binding portion (shown red), the hexanucleotide active sequence (highlighted red nucleotides), the SNV sensitive arm (shown blow) and blocking sequence (shown green). When hybridized with its target analyte, the blocking sequence is removed from the active sequence allowing MG fluorescence. Prospective linker site is highlighted magenta.