Table 4.
The relationship between preoperative anti-tumor necrosis factor alpha therapy and development of pouchitis within the first two years after ileal pouch-anal anastomosis, evaluated by time period of index surgery
| Adjusted HR (95% CI) | |
|---|---|
| All years (2006–2018) * | |
| Anti-TNF use | 1.14 (0.93 – 1.40) |
| No Anti-TNF use | Reference |
| 2006–2010 ** | |
| Anti-TNF use | 1.21 (0.85 – 1.70) |
| 2011–2014 ** | |
| Anti-TNF use | 1.03 (0.74 – 1.42) |
| 2015–2018 ** | |
| Anti-TNF use | 1.25 (0.82 – 1.87) |
*
Adjusted for sex, year of surgery, age and socioeconomic index
**
Adjusted for sex, age and socioeconomic index; no anti-TNF use is the reference for all comparisons presented above; p-value for interaction = 0.71