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. 2022 Nov 4;8(1):15. doi: 10.1038/s41514-022-00096-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — (a) The expression of two DEGs in brain tissues was validated in the Human Protein Atlas database. The x-axis represents the consensus normalized expression (nTPM) values. (b) DEGs were validated by using qRT-PCR (n = 20; 10 MCI-C and 10 MCI-NC). (c) High-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, non-HDL cholesterol, total cholesterol (T-CHO), and triglycerides (TG) were measured in routine blood tests. Their differences were examined between MCI-C and MCI-NC samples (n = 145; 52 MCI-C and 93 MCI-NC). Welch’s t-test was used to identify statistically significant difference between MCI-C and MCI-NC samples in the two DEGs and five items measured in routine blood tests (b, c). Data are represented as box and whisker plots, depicting minimum, lower quartile (Q1), median (Q2), upper quartile (Q3), and maximum values (b, c).