Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Nov 4;13:6634. doi: 10.1038/s41467-022-34316-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — a Representative immunoblot of the expression of FLAG-MTFP1 compared to endogenous MTFP1 levels in transgenic (Tg) Cardiomyocye^FLAG-MTFP1 mice constitutively expressing FLAG-MTFP1 in cardiomyocytes. Similar results were obtained with n = 4 biological replicates. b Volcano plot of the FLAG-MTFP1 interactome analyzed by mass spectrometry. (Purple) Mitochondrial proteins exclusively present in FLAG-MTFP1 eluates or significantly enriched greater than two-fold, listed in Supplementary Data 3. (Green) Non-mitochondrial proteins significantly more abundant in Tg heart. (Blue) Non-mitochondrial proteins significantly more abundant in WT heart. c Functional classification of 60 mitochondrial proteins identified in Co-IP eluates in b (Supplementary Data 3). d Second-dimension electrophoresis (2D BN-PAGE) of the cardiac OXPHOS complexes isolated from WT (top) and cMKO (bottom) mice at 8–10 weeks and previously separated in a BN-PAGE. Detection of components of the mPTP complex was performed using the indicated antibodies.