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. 2022 Nov 4;13:6643. doi: 10.1038/s41467-022-34274-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Schematic illustration of the generation of pancreas-specific expression of iRFP713 mice (iRFP713^flox/flox; Pdx1-Cre). b Whole-body imaging of iRFP713^flox/flox; Pdx1-Cre mice and control mice (8 weeks and 15 months). c NIR-II fluorescence imaging of the pancreas with laparotomy (left panel), the fluid-filled pancreas (middle three panels. Insert: the magnified image of the fluid-filled pancreas), and the isolated pancreas (right panel) of iRFP713^flox/flox; Pdx1-Cre mice. d NIR-II fluorescence imaging of the pancreas for iRFP713^flox/flox; Pdx1-Cre mice at various time points (days 0, 1, 3, 5, and 7) after STZ injections. The fluorescence intensity quantification for the pancreas is shown in the lower panel (n = 5 mice). e Brief description of the cerulein-induced pancreatitis experiment. Mice were administered 8 hourly doses of cerulein to induce acute pancreatitis. f NIR-II fluorescence imaging of the pancreas for iRFP713^flox/flox; Pdx1-Cre mice at various time points (0, 24, 48, 72 hours) after cerulein injections. Fluorescence intensity quantifications are shown to the right (n = 5 mice). Data presented as mean values ± SEM. Exposure times: 20 ms (b, d, f) and 10 ms (c). Scale bars: 5 mm (b, d, f) and 1 cm (c).