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. 2022 Nov 4;8:444. doi: 10.1038/s41420-022-01238-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A, B Correlation coefficient between signature genes (immunomodulators (A) and immune checkpoints (B)) and GPR35 expression level. C Relation between GPR35 expression level and infiltration level of various immune cells. D Cumulative survival for different infiltration levels of immune cells in GC patients. E The infiltration level of various immune cells under different copy numbers of GPR35 in GC. *, **, and *** represents p < 0.05, p < 0.01, and p < 0.001, respectively. F The infiltration level of macrophage M0 under different copy numbers of GPR35 in GC. P values were calculated with the Kruskal–Wallis test. G GPR35 expression level in stomach normal tissues, tumor-adjacent tissues, and STAD (GC) tumors. P value was calculated with the F-test.