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. 2022 Oct 19;8(11):e11183. doi: 10.1016/j.heliyon.2022.e11183

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© 2022 Published by Elsevier Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

(A) The effects of drugs on tumour cell apoptosis. Green spots represent apoptotic bodies, and blue spots represent cell nuclei (400×). (B) The effects of drugs on the expression of cleaved caspase-3 in tumour tissue (400×). (C) Cleaved caspase 3 and corresponding frequencies of TUNEL positive cells expressed as AI. Different marks within treatments indicate significant differences at ∗p < 0.05 and ∗∗p < 0.01 compared to the TC group (n = 3). (D) Weight change trends in 10 acutely toxic experimental mice.