TABLE 1.

Dose schedules

Dose escalation schedule A
Dose Level	Dose
	Carboplatin (AUC) IV Day 1	Paclitaxel (mg/m2) IV Days 1, 8, 15	Talazoparib (BMN 673) (mcg) PO once daily Days 1–7
Level − 1	5	80	100
Level 1a	5	80	250
Level 2	6	80	250
Level 3	6	80	350
Level 4	6	80	500
Level 5	6	80	750
Level 6	6	80	1000

Dose escalation schedule B
Dose level	Dose
	Carboplatin (AUC) IV Day 1	Paclitaxel (mg/m2) IV Days 1, 8, 15	Talazoparib (BMN 673) (mcg) PO once daily Days 1–3
Level 1	5	80	250
Level 1 a	6	80	250
Level 2	6	80	350
Level 3	6	80	500
Level 4	6	80	750
Level 5	6	80	1000

^a Starting dose level for each schedule.