. 2022 Mar 29;11(21):4033–4042. doi: 10.1002/cam4.4718

TABLE 2.

Frequency of P16 methylation in biopsy and cytology specimens

Diagnosis	n	Biopsy specimens		Cytology specimens		p‐value (biopsy vs. Cytology)
Diagnosis	n	Case with P16 methylation (%)	p‐value	Case with P16 methylation (%)	p‐value	p‐value (biopsy vs. Cytology)
No dysplasia	62	1 (1.6)		3 (4.8)		0.611 ^b
LGIN	12	1 (8.3)	0.300 ^a	3 (25.0)	0.050 ^a	0.590 ^b
HGIN	8	1 (12.5)	0.217 ^a	3 (37.5)	0.017 ^a	0.569 ^b
ESCC	23	7 (30.4)	<0.001 ^a	10 (43.5)	<0.001 ^a	0.359 ^b
Trend		p for trend <0.001		p for trend <0.001

No dysplasia, normal esophagus and esophagitis; LGIN, low‐grade intraepithelial neoplasia; HGIN, high‐grade intraepithelial neoplasia; ESCC, esophageal squamous cell carcinoma.

The bold values indicate p < 0.05.

^{^a}

Compared with no dysplasia.

^{^b}

Compared between biopsy specimen and cytology specimen.