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Recombinant WT PFFs induce neurological disease in TgM20+/− mice. Eight-week-old TgM20+/− mice were inoculated with either control patient samples (C9 and C17) or recombinant WT PFFs. Kaplan–Meier plot of disease onset in TgM20+/− mice shows control-inoculated mice did not develop disease by 475 days postinoculation (dpi), but WT PFF-inoculated mice developed overt motor deficits 210 ± 37 dpi (*** = P < 0.001)
