Table 4.
Univariate and multivariate analyses of OS with Cox regression models
| Covariate | Univariate analysis (n = 74) | Multivariate analysis (n = 74) | ||||||
|---|---|---|---|---|---|---|---|---|
| Exp(B) | 95.0% CI | Exp(B) | 95.0% CI | |||||
| Lower | Upper | P -value | Lower | Upper | P -value | |||
| Group | ||||||||
| non-irAE | Reference | Reference | ||||||
| irAE | 0.515 | 0.254 | 1.044 | 0.066 | 0.269 | 0.088 | 0.822 | 0.021 |
| ECOG PS | ||||||||
| 0 | Reference | Reference | ||||||
| ≥ 1 | 1.207 | 0.502 | 2.900 | 0.674 | 1.418 | 0.557 | 3.611 | 0.464 |
| Treatment line | ||||||||
| 1–2 | Reference | Reference | ||||||
| 3–4 | 1.915 | 0.867 | 4.228 | 0.108 | 1.851 | 0.697 | 4.917 | 0.217 |
| Number of Metastatic Sites | ||||||||
| < 2 | Reference | Reference | ||||||
| ≥ 2 | 1.476 | 0.557 | 3.909 | 0.434 | 1.806 | 0.467 | 6.987 | 0.392 |
| Disease Status | ||||||||
| stage III-IV | Reference | Reference | ||||||
| recurrence | 1.553 | 0.726 | 3.324 | 0.257 | 3.252 | 1.138 | 9.292 | 0.028 |
| ALP | ||||||||
| low | Reference | Reference | ||||||
| high | 1.652 | 0.859 | 3.177 | 0.133 | 2.035 | 1.022 | 4.051 | 0.043 |
| NLR | ||||||||
| low (< 4) | Reference | Reference | ||||||
| high (≥ 4) | 1.506 | 0.744 | 3.049 | 0.255 | 1.030 | 0.413 | 2.570 | 0.950 |
Abbreviations: ECOG PS Eastern Cooperative Oncology Group performance status, NLR Neutrophilto-lymphocyte ratio, ALP Alkaline phosphatase