Table 5.

Relationship between immune-related adverse events and PFS and OS

	PFS				OS
	Univariable HR (95% CI)	P -value	Multivariable HR (95% CI)	P -value	Univariable HR (95% CI)	P -value	Multivariable HR (95% CI)	P -value
Hypothyroidism/Hyperthyroidism	0.332 (0.131–0.842)	0.020	0.291 (0.110–0.768)	0.013	0.515 (0.199–1.334)	0.172	0.518 (0.197–1.361)	0.182
Diarrhea/Colitis	0.743 (0.181–3.060)	0.681	0.365 (0.083–1.610)	0.183	0.350 (0.048–2.562)	0.301	0.167 (0.020–1.403)	0.099
Rash/Pruritus/Myalgia/Fatigue	0.078 (0.011–0.579)	0.013	0.065 (0.008–0.501)	0.009	0.213 (0.029–1.558)	0.128	0.216 (0.029–1.590)	0.132
Hypohemoglobin/Thrombocytopenia	1.469 (0.356–6.057)	0.595	1.209 (0.290–5.038)	0.794	2.240 (0.573–10.218)	0.229	4.460 (0.935–21.279)	0.061
Damage of liver or kidney function/Myocardial enzyme increased	1.970 (0.710–5.464)	0.193	2.778 (0.994–7.764)	0.051	1.261 (0.376–4.232)	0.707	1.066 (0.314–3.625)	0.918