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. 2022 Nov 5;15:163. doi: 10.1186/s13045-022-01376-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — CD123 is highly expressed on primary blasts collected from paediatric AML patients. A Percentage of CD123 expression levels in primary BM cells obtained from AML patients (triangles) and HD (circles) were assessed by flow cytometry analysis, across 3 main haematopoietic cell subpopulations, namely the mature CD38⁺CD34⁻ cells, the intermediate CD38⁺ CD34⁺ cells, and the most immature CD38⁻ CD34⁺ stem cells. The gating strategy is shown in Additional file 1: Fig. S1. B Median fluorescence intensity (MFI) for CD123 on AML primary blasts or BM-derived cells from HDs. MFI was adjusted for cell size by dividing MFI by the forward scatter (FSC). C Geometric mean fluorescence intensities (GeoMean) of CD123 on AML primary blasts or BM-derived cells from HDs. Data are shown as average ± SD. *p < 0.05, **p < 0.01, ***p ≤ 0.001. D The heatmap shows the CD123 MFI detected on HSC precursors from BM of AML patients and HDs