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. 2022 Nov 4;13:63. doi: 10.1186/s13293-022-00474-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Statin effects on hepatic gene expression are influenced in distinct ways by gonadal and chromosomal sex. A Venn diagram shows number of genes altered by statin treatment depending on presence of ovaries or testes, and the minimal overlap between the two. MA plots display mean expression levels and fold-change of differentially expressed genes (DESeq2, > 1.25-fold altered expression, P < 0.05) in B statin-treated mice with testes compared to chow diet controls and C statin-treated mice with ovaries compared to chow diet controls. Significantly enriched cellular pathways for statin-induced gene expression changes in D mice with testes and E mice with ovaries (no enriched pathways). F Venn diagram shows number of genes altered by statin treatment depending on presence of XX or XY chromosomes, and the minimal overlap between the two. MA plots display mean expression levels and fold-change of differentially expressed genes (DESeq2) in G statin-treated XY mice compared to chow diet controls and H statin-treated XX mice compared to chow diet controls. Significantly enriched cellular pathways for statin-induced gene expression changes in I XY mice and J XX mice (no enriched pathways)