Table 1.
Characteristics of study participants
| Characteristic | Frequency (n = 212) | Percentage | |||
|---|---|---|---|---|---|
| DRTB treatment site | |||||
| Lira Regional Referral Hospital (Northern region) | 85 | 40.1 | |||
| Mulago National Referral Hospital (Central region) | 83 | 39.1 | |||
| Mbale Regional Referral Hospital (Eastern region) | 25 | 11.8 | |||
| Mbarara Regional Referral Hospital (Western region) | 19 | 9.0 | |||
| Rural residence | 128 | 60.4 | |||
| Married | 112 | 52.8 | |||
| Education (n = 211) | |||||
| None | 18 | 8.5 | |||
| Primary-level education | 122 | 57.8 | |||
| Secondary-level education | 55 | 26.1 | |||
| Tertiary-level education | 16 | 7.6 | |||
| Employment status | |||||
| Peasant farmer | 92 | 43.4 | |||
| Self employed | 48 | 22.6 | |||
| Unemployed | 38 | 17.9 | |||
| Formal employment | 34 | 16.0 | |||
| Family history of cardiovascular disease (n=98) | |||||
| Hypertension | 55 | 56.1 | |||
| Diabetes mellitus | 25 | 25.5 | |||
| Obesity (n = 97) | 8 | 8.3 | |||
| Heart failure (n=97) | 8 | 8.3 | |||
| Kidney disease | 7 | 7.1 | |||
| Stroke | 6 | 6.1 | |||
| Premature CVD death in first degree relative** | 5 | 5.1 | |||
| Any history of alcohol use | 148 | 69.8 | |||
| Type of DRTB at Baseline (n = 210) | |||||
| Rifampicin resistance/multidrug resistant | 204 | 96.2 | |||
| Pre- XDRTB | 3 | 1.43 | |||
| Poly resistant tuberculosis | 1 | 0.5 | |||
| XDR-TB | 1 | 0.5 | |||
| Mono-resistance | 1 | 0.5 | |||
| Previous TB episode (n = 210) | 112 | 53.3 | |||
| Mycobacterial load at treatment initiation* (n = 170) | |||||
| High | 52 | 30.6 | |||
| Medium | 35 | 20.6 | |||
| Low | 28 | 16.5 | |||
| Very low | 55 | 32.4 | |||
| Drugs in the treatment regimen (n = 209) | |||||
| Levofloxacin | 200 | 95.7 | |||
| Cycloserine | 197 | 94.3 | |||
| Clofazimine | 197 | 94.3 | |||
| Linezolid | 165 | 79.0 | |||
| Bedaquiline | 157 | 75.1 | |||
| Pyrazinamide | 39 | 18.7 | |||
| Ethionamide | 10 | 4.8 | |||
| Delamanid | 8 | 3.8 | |||
| Ethambutol | 6 | 2.9 | |||
| Moxifloxacin | 2 | 1.0 | |||
| Amikacin | 1 | 0.5 | |||
| Time from diagnosis to treatment (days), median (IQR), n= 202 | 8 (5 – 14) | ||||
*Determined by cycle threshold values of the MTB Xpert/Rif assay. ** (age <55 for male and <65 for female relatives). Abbreviations: DRTB – drug resistant tuberculosis, CVD – cardiovascular disease, XDRTB – extensively drug resistant tuberculosis (defined as resistance to rifampicin, isoniazid, a fluoroquinolone and an injectable aminoglycoside)