Figure 3.
Synaptic vulnerability to extrinsic Aβ insults in patient iPSC-derived cortical neurons remained consistent across neuronal differentiation repeats and types of Aβ insults. Pairwise comparisons of the degrees of synapse loss between neuronal differentiation repeats caused by Aβ1-42, Aβ25-35 oligomers or Alzheimer’s disease brain homogenate. The same three selected patient lines from Fig. 2 are highlighted in the graphs. Pearson’s coefficient of correlation and its P-value were reported for statistical analysis.