Figure 4.

Synapse loss due to Aβ insults in vitro reflects clinical vulnerability in the same patients to Aβ burden in vivo. Pairwise comparisons between the percentage of synapse loss and clinical vulnerability quotients. Each row denotes the type of extrinsic Aβ insult used to induce synapse loss and each column denotes the selected clinical outcomes which have been corrected for Aβ_1-42 concentration in the CSF (MMSE score loss rate) or amyloid PET SUVR (MEG). Error band: 95% confidence interval (CI). n = 35 (Aβ_1-42—MMSE score loss rate), 36 (Aβ_25-35 and Alzheimer’s disease brain homogenate—MMSE score loss rate) and 24 (all MEG) independent neuronal differentiation repeats per patient line. Pearson’s coefficient of correlation and its P-value were reported for statistical analysis.