Table 1.

Structural adaptions of omicron RBD residues to mACE2 or hACE2

Omicron RBD residues	Omicron residues are adapted to which ACE2 residues?
Arg493	Adapted to Asn31 in mACE2 (Incompatible with Lys31 in hACE2)
His505	Adapted to His353 in mACE2 (Incompatible with Lys353 in hACE2)
Arg498	Adapted to His353 in mACE2 (Incompatible with Lys353 in hACE2); Adapted to Asp38 in both hACE2 and mACE2
Tyr501	Adapted to Tyr41 in both hACE2 and mACE2; Adapted to Lys353 in hACE2 and His353 in mACE2
Asn477	Adapted to N-terminal residues in hACE2 (Neutral with N-terminal residues in mACE2)
Lys478	Largely neutral with hACE2 and mACE2
Ala484	Largely neutral with hACE2 and mACE2