Table 2.
Clinicopathological factors in urine of DKD patients.
| Clinical parameters | Control (n = 30) | Group 1 (n = 30) | Group 2 (n = 30) | Group 3 (n = 30) |
|---|---|---|---|---|
| UACR (mg/L) | 11.5 ± 2.45 | 82.5 ± 20.77∗ | 663.7 ± 119.84# | 2803.5 ± 864.35# |
| AIF-1 (pg/mL) | 40.3 ± 3.23 | 60.5 ± 5.42∗ | 107.6 ± 9.41# | 209.1 ± 18.2# |
| miR-34a (fold) | 1.1 ± 0.16 | 1.8 ± 0.21∗ | 3.2 ± 0.35# | 5.3 ± 0.76# |
| NLRP3 (ng/ml) | 0.9 ± 0.14 | 1.5 ± 0.16∗ | 5.5 ± 0.87# | 7.3 ± 1.25# |
| ATG4B (ng/ml) | 15.2 ± 2.23 | 12.7 ± 1.66∗ | 9.1 ± 1.13# | 3.8 ± 0.84# |
| IL-1β (pg/mL) | 0.5 ± 0.13 | 2.2 ± 0.25∗ | 7.2 ± 1.55# | 11.5 ± 2.43# |
| IL-18 (pg/mL) | 6.5 ± 1.29 | 20.5 ± 3.71∗ | 48.2 ± 4.81# | 60.1 ± 5.68# |
Control: healthy people; UACR: urea albumin creatinine ratio; AIF-1: allograft inflammatory factor-1; miR-34a: microRNA 34a; ATG4B: autophagy related 4 homolog B; NLRP3: NOD-like receptor thermal protein domain associated protein 3; IL-1β: interleukin 1β; IL-18: interleukin 18; Group 1: 30 mg/g ≤ ACR ≤ 300 mg/g; Group 2: ACR > 300 mg/g; Group 3: normal control group; versus control, ∗P < 0.01, #P < 0.001.