Table 3.
The levels of biochemical indexes and inflammatory factors in db/db mice for 4-12 weeks (n = 6).
| Parameters | db/m mice | db/db mice | ||
|---|---|---|---|---|
| 4-12 weeks | 4 weeks | 8 weeks | 12 weeks | |
| Blood glucose (mmol/L) | 9.3 ± 2.42 | 17.7 ± 3.61∗ | 24.8 ± 4.33# | 26.4 ± 5.03# |
| Total cholesterol (mmol/L) | 2.5 ± 0.41 | 3.9 ± 0.85 | 4.5 ± 1.08∗ | 5.8 ± 1.14# |
| Triglycerides (mmol/L) | 1.1 ± 0.12 | 1.7 ± 0.28 | 3.4 ± 0.64∗ | 6.2 ± 1.38# |
| Serum creatinine (mg/L) | 0.2 ± 0.08 | 0.3 ± 0.11 | 0.5 ± 0.17∗ | 1.2 ± 0.25# |
| BUN (mmol/L) | 8.7 ± 3.19 | 9.3 ± 3.76 | 9.7 ± 4.41 | 11.4 ± 4.97∗ |
| UACR (μg/mg) | 32.6 ± 6.15 | 64.1 ± 10.39∗ | 78.7 ± 12.51# | 93.5 ± 14.72# |
| AST (unit/L) | 21.8 ± 4.76 | 25.7 ± 5.15 | 27.1 ± 5.68 | 25.2 ± 5.47 |
| ALT (unit/L) | 41.4 ± 7.11 | 48.2 ± 6.92 | 52.4 ± 8.93 | 51.4 ± 8.17 |
| Total protein (g/dL) | 4.3 ± 1.13 | 3.9 ± 0.97 | 3.4 ± 0.81∗ | 3.1 ± 0.76∗ |
| AIF-1 (pg/mL) | 4.3 ± 1.12 | 12.5 ± 2.34∗ | 25.2 ± 3.54# | 45.6 ± 5.2# |
| miR-34a (fold) | 0.9 ± 0.11 | 1.3 ± 0.12∗ | 2.1 ± 0.25# | 3.5 ± 0.37# |
| NLRP3 (ng/ml) | 1.2 ± 0.22 | 2.6 ± 0.32∗ | 5.7 ± 1.62# | 12.5 ± 2.25# |
| ATG4B (ng/ml) | 8.1 ± 1.81 | 6.7 ± 1.52∗ | 4.5 ± 0.89# | 1.5 ± 0.32# |
| IL-1β (pg/mL) | 1.1 ± 0.21 | 2.3 ± 0.31∗ | 5.8 ± 0.92# | 9.5 ± 1.83# |
| IL-18 (pg/mL) | 5.1 ± 1.15 | 9.7 ± 2.17∗ | 16.5 ± 3.19# | 26.5 ± 3.46# |
BUN: urea nitrogen; UACR: urea albumin creatinine ratio; AST: aspartate aminotransferase; ALT: alanine transaminase; AIF-1: allograft inflammatory factor-1; miR-34a: microRNA 34a; ATG4B: autophagy related 4 homolog B; NLRP3: NOD-like receptor thermal protein domain associated protein 3; IL-1β: interleukin 1β; IL-18: interleukin 18; versus db/m mice, ∗P < 0.01, #P < 0.001.