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. 2022 Oct 28;90(6):511–521. doi: 10.1007/s00280-022-04488-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Distributions of the simulated ipatasertib AUC_SS in the IPATential150 study population by AUC_SS quartile (left panel) or as overall (right panel). Filled circles represent the simulated exposure of individual patients. Annotations represent medians in each group. Solid bold lines, shaded boxes, and whiskers in the box plots represent the medians, interquartile ranges, and 1.5 times the interquartile range, respectively. AUC_SS area under the concentration–time curve at steady state, AUC_SSQ AUC_SS Quartiles