Fig. 1. Inhibition of leukemogenesis by UM171 in culture and in vivo.

A Structure of UM171. B UM171 at indicated concentration inhibits proliferation of HEL cells in culture. C IC₅₀ analysis of UM171 for the indicated cell lines. D Macroscopic image of apoptotic cells after treatment of HEL cells with 1.6 μM of UM171 (original magnification X20, scale bars, 100 μm). E UM171 induces apoptosis of HEL cells at the indicated concentrations. F UM171 induces G₁/S cell cycle arrest of HEL cell at indicated concentrations. G Newborn BALB/c mice infected with F-MuLV were treated for two weeks with UM171 (3 mg/ Kg), 5 weeks postviral infection, and plotted after all mice succumbed to leukemia. H, I UM171 treated mice with their hematocrit values (H) and tumor volume (I) at the time of death.