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. 2022 Nov 5;13:6686. doi: 10.1038/s41467-022-34492-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Panels (a) and (b) present the distribution of the CMR Score, measuring Carcinogenicity (C), Mutagenicity (M), and Reproductive toxicity (R), and the Environmental Score, measuring environmental hazard, across the five examined chemical lists. Note that some compounds could not be assigned a score as there was no matching entry in the classification and labeling inventory. Sample size (a): European chemical regulation Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH, n = 16,846), Candidate List (CL, n = 247), Authorization List (AL, n = 79), SIN List (SIN, n = 877), PRIO List (PRIO, n = 848). The parallel bars represent the median value while the hinges show the first and third quartiles. The whisker extends 1.5 inter-quartile ranges from the hinge. Outliers are plotted as individual points.