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. 2022 Nov 5;13:6686. doi: 10.1038/s41467-022-34492-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The figure presents the point estimates of the odds ratio and the corresponding 95% confidence interval for all parameters included in the logit model where the likelihood of inclusion on the Candidate List is predicted by the toxicological properties of the substances as well as the economic and knowledge parameters. Chemicals listed in the Candidate List are compared to (a) all chemicals registered under the European chemical regulation Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH, n = 15,169), (b) chemicals listed on the SIN list (SIN, n = 874), and (c) chemicals listed on the PRIO list (PRIO, n = 856). Parameters with estimates to the left of the vertical line at 1 will typically be of lower value in the Candidate List as compared to the list with which it is compared, and vice versa.