Table 1.
Mean comparisons across lists of chemical substances
| Mean | REACH (1) | CL (2) | AL (3) | SIN (4) | PRIO (5) | REACH-CL (6) | AL_CL (7) | SIN_CL (8) | PRIO_CL (9) |
|---|---|---|---|---|---|---|---|---|---|
| Toxicological parameters | |||||||||
| CMR Score | 0.03 (0.10) | 0.29 (0.26) | 0.27 (0.27) | 0.37 (0.26) | 0.32 (0.26) | 2.5E−131*** | 4.6E−01 | 4.4E−06*** | 3.1E−01 |
| Carcinogenicity Warning | 0.02 (0.12) | 0.07 (0.44) | 0.04 (0.46) | 0.05 (0.46) | 0.06 (0.48) | 7.8E−09*** | 1.8E−01 | 4.6E−02** | 3.2E−01 |
| Carcinogenicity Danger | 0.03 (0.15) | 0.28 (0.44) | 0.32 (0.46) | 0.55 (0.46) | 0.42 (0.48) | 1.4E−80*** | 3.7E−01 | 8.9E−22*** | 1.6E−06*** |
| Mutagenicity Warning | 0.03 (0.14) | 0.18 (0.37) | 0.15 (0.34) | 0.30 (0.42) | 0.21 (0.39) | 1.3E−21*** | 2.1E−01 | 3.4E−02** | 1.2E−02** |
| Mutagenicity Danger | 0.01 (0.09) | 0.09 (0.27) | 0.08 (0.27) | 0.16 (0.33) | 0.05 (0.22) | 6.3E−22*** | 9.3E−01 | 2.5E−04*** | 9.8E−03** |
| Reproduction Warning | 0.02 (0.14) | 0.12 (0.30) | 0.09 (0.24) | 0.12 (0.26) | 0.06 (0.21) | 2.3E−20*** | 2.4E−01 | 9.9E−01 | 7.2E−06*** |
| Reproduction Danger | 0.02 (0.12) | 0.37 (0.47) | 0.33 (0.46) | 0.25 (0.41) | 0.34 (0.46) | 6.3E−139*** | 3.5E−01 | 2.0E−08*** | 1.1E−01 |
| Environmental Score | 0.08 (0.24) | 0.40 (0.45) | 0.40 (0.44) | 0.31 (0.43) | 0.51 (0.47) | 2.0E−62*** | 8.8E−01 | 6.2E−04*** | 3.9E−05*** |
| Acute Environmental Warning | 0.09 (0.26) | 0.40 (0.46) | 0.43 (0.47) | 0.31 (0.44) | 0.51 (0.48) | 6.8E−56*** | 5.1E−01 | 3.0E−04*** | 3.1E−04*** |
| Chronic Environmental Warning | 0.08 (0.25) | 0.39 (0.46) | 0.37 (0.46) | 0.31 (0.43) | 0.52 (0.48) | 7.3E−59*** | 7.0E−01 | 2.0E−03** | 9.8E−06*** |
| Economic parameters | |||||||||
| Tonnage Band | 1.56 (1.69) | 1.51 (2.00) | 1.41 (1.91) | 2.33 (2.67) | 0.40 (1.24) | 6.0E−01 | 5.6E−01 | 2.9E−07*** | 5.0E−41*** |
| #Countriesa | 1.36 (0.56) | 1.04 (1.36) | 0.81 (1.29) | 1.53 (1.65) | 0.10 (0.65) | 7.4E−04*** | 2.6E−01 | 2.3E−02** | 3.0E−43*** |
| Knowledge parameters | |||||||||
| Publication Rank | 0.22 (0.58) | 0.87 (1.07) | 0.82 (1.02) | 0.67 (1.02) | 0.36 (0.80) | 2.0E−63*** | 5.5E−01 | 4.0E−06*** | 4.6E−29*** |
Cols (1)–(5) report the mean value and standard deviation (in parentheses) of the toxicological, economic, and knowledge parameters.
Cols (6)–(9) report the p-value and statistical significance of a two-way t-test comparing the mean value of the parameters of interest for the chemicals included in the Candidate List (CL) to those listed under the European chemical regulation Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH), Authorization List (AL), SIN List (SIN), and PRIO List (PRIO), respectively.
The CMR Score measures Carcinogenicity (C), Mutagenicity (M), and Reproductive toxicity (R), and the Environmental Score measures environmental hazard.
***Significant at 0.01, **Significant at 0.05, *Significant at 0.1.
aMean and standard deviation for the number of registered countries were based on the variance-stabilizing transformed data.