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. 2022 Nov 5;13:6678. doi: 10.1038/s41467-022-34152-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Hierarchical clustering of top 1000 genes having the highest normalized PCRI variances across cell types. Representative GO terms enriched for the corresponding set of genes are shown on the right. b Histone modification landscape around the transcription start site of CCN2 and its pCREs in Liver (E066) and HepG2 (E118) cells. Red shades denote promoter regions and blue shades denote pCRE regions interacting with the promoter. Red arrow represents a putative enhancer region that seems to be only active in HepG2 cells. Source data are provided as a Source Data file.