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. 2022 Nov 5;13:6668. doi: 10.1038/s41467-022-34383-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Manhattan plots of four association scans with platelet crit. From top to bottom plots are shown results for additive (black), maternal (red), paternal (blue) and differential (green) scans. The lead variant mentioned in this study (rs59228823) is shown with a diamond. Red horizontal lines indicate genome-wide significance threshold at −log10(5 × 10⁻⁰⁸). b Locus zoom at rs59228823 on the differential scan. c Box plot of the normalized platelet crit (y-axis) stratified by risk alleles and origin at SNP rs59228823; paternal in blue and maternal in red (x-axis). The horizontal dotted lines represent the phenotypic median of the major allele G. Boxes bound the 25th, 50th (median), and the 75th quantiles. Whiskers range from minima (lower) to maxima (upper). Sample sizes are n_paternal(G/C) = 16,285/4,769 and n_maternal(G/C) = 16,368/4686 individuals. N.S non-significant (p-value = 0.66); ***=significant (p-value = 6.6 × 10⁻¹⁷) (computed with BOLT-LMM¹⁸). Source data for (a) and (b) are provided as a Source Data file.