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. 2022 Nov 5;12:18776. doi: 10.1038/s41598-022-23544-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Mitochondrial complexes were decreased in the S group. The subunits of each mitochondrial complexes are represented. The subunits that were not identified in the proteomic dataset are not shown (Complex I : MT-ND2, MT-ND3, MT-ND6; Complex III : MY-CYB, UQCRHL; Complex IV : COX4l2, COX6B2, COX7B, COX7B2, COX8C, COX10, COX15; Complex V : ATP5MF). The bar represents the mean difference (Log 2 Fold Change) between the S group and the two control groups, the error bar represents the 95% confidence interval. N = 31 patients analyzed for the proteomics (Septic shock n = 12, cardiogenic shock n = 9, brain dead n = 10). *p < 0.05; **p < 0.01; ***p < 0.001 (Tukey’s post-hoc test, Group S versus Reference).