Table 2.

Associations between weighted gene co-expression network analysis module eigenvalues and incident type 2 diabetes

Modules	Q1	Q2 (ORs [95% CI])	Q3 (ORs [95% CI])	Q4 (ORs [95% CI])	Ptrend
Blue: TGs, DGs and PCs with a 22:6 fatty acid and other LCFA; number of lipid species = 35
	1	1.03(0.51–2.07)	1.61(0.81–3.20)	2.18(1.13–4.22)	0.012
Red: ether-PCs and ether-PEs with an unsaturated-LCFA; number of lipid species = 16
	1	0.74(0.38–1.44)	0.99(0.47–2.09)	1.08(0.52–2.26)	0.700
Green: ether-PCs with a saturated-LCFA; number of lipid species = 18
	1	1.76(0.93–3.32)	1.25(0.63–2.48)	1.21(0.53–2.77)	0.322
Yellow: SMs with LCFA; number of lipid species = 25
	1	1.64(0.81–3.30)	1.28(0.62–2.67)	1.39(0.64–3.02)	0.457
Pink: TGs with at least one 18:2 FA; number of lipid species = 13
	1	0.88(0.44–1.73)	0.84(0.42–1.68)	1.46(0.75–2.84)	0.121
Green-yellow: DGs with LCFA; number of lipid species = 10
	1	0.66(0.32–1.36)	0.80(0.38–1.69)	0.52(0.22–1.27)	0.709
Black: PEs with a saturated-LCFA and an unsaturated-LCFA; number of lipid species = 14
	1	1.47(0.78–2.77)	1.64(0.83–3.24)	1.32(0.62–2.82)	0.073
Turquoise: TGs containing LCFA with less than 2 double bonds and PCs with LCFA; number of lipid species = 47
	1	0.63(0.32–1.23)	0.74(0.36–1.52)	1.03(0.48–2.21)	0.209
Brown: LPCs and ether LPCs containing LCFA and VLCFA; number of lipid species = 30
	1	0.64(0.33–1.25)	0.21(0.09–0.47)	0.55(0.27–1.12)	0.035

The results of the modules significantly correlated to incident type 2 diabetes were shown. Boldface type indicates p for trend < 0.05 for the association with type 2 diabetes. The model is adjusted for BMI, TG/HDL ratio and prediabetes

OR odds ratio, BMI body mass index, TG triacylglycerol, HDL high-density lipoprotein, LCFA long-chain fatty acid, VLCFA very-long-chain fatty acid, DG diacylglycerol, PC phosphatidylcholine, PE phosphatidylethanolamine, LPC lyso-phosphatidylcholine, Cer ceramide, SM sphingomyelin