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. Author manuscript; available in PMC: 2022 Nov 6.
Published in final edited form as: Oncogene. 2018 Mar 8;37(22):2953–2966. doi: 10.1038/s41388-018-0177-4

Fig. 2.

Fig. 2

FAK blockade prevents psychological depression-promoted tumor metastasis and desmolpasia in the orthotropic 22Rv1 model. a Time course of restraint stress and tumor implantation. b Body weight of mice (n = 10). The statistical analysis was based on Two-way ANOVA with Bonferroni posttests (shNC non-stress vs shNC stress, from week 4 to week 7, ***P < 0.001; shPTK2 non-stress vs shPTK2 stress, from week 4 to week 7, ***P < 0.001). c Sucrose consumption ratio in the sucrose preference test (n = 10). The statistical analysis was based on One-way ANOVA with Tukey’s post-hoc tests (***P < 0.001). d Illustrative examples of in vivo bioluminescence imaging of 22Rv1 cells orthotropic implanted in the ventral prostate of nu/nu mice (n = 5). e ROI analysis of fluorescence intensities from the 22Rv1 cells orthotropic tumors (n = 10). The statistical analysis was based on One-way ANOVA with Tukey’s post-hoc tests (*P < 0.05). f Representative fluorescence images of metastatic sites in the 22Rv1 model. g H&E and Masson staining of the prostate in the 22Rv1 model. Bar: 50 µm