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. Author manuscript; available in PMC: 2022 Nov 6.
Published in final edited form as: World J Gastoentrol Hepatol Endosc. 2020 Oct 8;3(3):WJGHE-1-122. doi: 10.47690/wjghe.2020.3303

Figure 4: Quantified fluorescence intensities.

Figure 4:

A) Scatter plot shows individual values for specimens of biliary neoplasia, including BilIN-1, BilIN-2, BilIN-3, and CCA, compared with that for normal epithelium. Differences in mean results are significant for QRH*-FITC (EGFR), RTS*-Cy5 (claudin-1), and KSP*-IRDye800 (ErbB2) with P = 6×10-3, 7×10-3, and 2×10-3 by unpaired t-test, respectively. ROC curves show optimal sensitivity and specificity of B) 75% and 88% for EGFR, C) 75% and 81% for claudin-1, and D) 69% and 81% for ErbB2 with AUC of 0.78, 0.78, and 0.80, respectively.