Table II.
Concordance of mosaic results at TE biopsy with the rest of the embryo/ICM.
| Study | Putative mosaic range | Mosaic embryos | Concordance with rest of the embryo |
Concordance with ICM |
Comments | ||||
|---|---|---|---|---|---|---|---|---|---|
| Mosaic | Aneuploid | Euploid | Mosaic | Aneuploid | Euploid | ||||
| Kim et al. (2022) | Whole chromosome mosaic | Confirmation rate: 2.1% | |||||||
|
| |||||||||
| Segmental mosaic | Confirmation rate: 2.2% | ||||||||
|
| |||||||||
| Segmental aneuploid | Confirmation rate: 42.1% | ||||||||
|
| |||||||||
| Capalbo et al. (2021) | 20–30% | 37 low-grade (4 TE biopsies per embryo) | 0 | 148 | ICM results were classified as normal (<50%) or abnormal (>50%) | ||||
|
| |||||||||
| 30–50% | Medium-grade mosaic (4 TE biopsies per embryo) | 1 | 45 | ||||||
|
| |||||||||
| 50–70% | 5 high-grade mosaic (4 TE biopsies per embryo) | 13 | 7 | ||||||
|
| |||||||||
| Wu et al. (2021) | 101: | 22 (22.9%) | 9 (9.4%) | 65 (67.7%) | 25 (27.5%) | 8 (8.8%) | 58 (63.7%) | ||
| – 96 results for TE | |||||||||
| – 91 results for ICM | |||||||||
|
| |||||||||
| Navratil et al. (2020) | 30–80% | 26 | 7 | 1 | 18 | ||||
|
| |||||||||
| Sachdev et al. (2020) | 18 mosaic embryos –19 biopsies from 13 ICM samples available | 4/19 (21.1%) | Data difficult to extract | ||||||
|
| |||||||||
| Fragouli et al. (2019) | 16 mosaic whole chromosome errors | 8 (50%) | 8 (50%) | Data from Munné and Wells, 2017 | |||||
|
| |||||||||
| 15 mosaic segmental chromosome errors | 7 (47%) | 8 (53%) | |||||||
|
| |||||||||
| 12 mosaic complex chromosome errors | 10 (83%) | 2 (17%) | |||||||
|
| |||||||||
| Chuang et al. (2018) | 20–80% | 5 | 2 | 2 | 1 | ||||
|
| |||||||||
| Popovic et al. (2018) | 16 | 3 | 7 | 6 | Pretested embryos only | ||||
TE, trophectoderm; ICM, inner cell mass.