Fig. 7.

Knockdown OPN expression inhibits MSC recruitment and lung metastasis in vivo. (A) A549-L-Luc cells were injected into the right lungs of nude mice and tumor growth was monitored by bioluminescence imaging at baseline and on Day 35. (B) On Day 35, the mice were sacrificed, and the lungs were excised and photographed. (C) Survival rates over 35 days of mice in the control (B[α]P or CSE) and OPN shRNA groups. (D) Lung specimens from sacrificed mice were stained with OPN and MSC markers (CD29, CD44 and CD105).