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. 2022 Jan 29;41:113–128. doi: 10.1016/j.jare.2022.01.013

Fig. 7.

Fig. 7

A151 ODN loaded exosomes produced under 3D conditions (A151-loaded Exo3D) modulate pro-inflammatory cytokine levels in vivo. Serum levels of IL-6 and TNF-α of mice treated with Exo3D, Exo2D, A151-loaded Exo3D, A151-loaded Exo2D, A151 ODN or PBS (CTRL), as controls, were determined by ELISA at days 7 (A) and 14 (B). Data is shown as mean ± SEM. n = 2–7. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001. Abbreviations: Exo3D - exosomes derived from UC-MSC cultured in 3D conditions; Exo2D - exosomes derived from UC-MSC cultured in 2D conditions; A151 ODN - immunosuppressor A151 oligodeoxynucleotide; A151-loaded Exo3D - exosomes produced under 3D culture conditions loaded with A151 ODN; A151-loaded Exo2D - exosomes produced under 2D culture conditions loaded with A151 ODN.