Table 2.
Performance comparison of the hybrid models with different combinations of protein descriptors.
| Core structure (Encoding) | DNN (Feature) | ACC (%) | F-value (%) | Recall (%) | PRE (%) | MCC |
|---|---|---|---|---|---|---|
| AAC | 88.8 | 88.2 | 87.1 | 89.5 | 0.776 | |
| TC | 87.6 | 87.5 | 88.7 | 86.5 | 0.754 | |
| PSSM | 87.5 | 86.8 | 85.9 | 88.0 | 0.751 | |
| DC | 88.2 | 87.9 | 88.8 | 87.3 | 0.766 | |
| CTD | 89.5 | 89.0 | 89.0 | 89.2 | 0.791 | |
| TC_CTD | 88.6 | 88.3 | 89.0 | 87.8 | 0.772 | |
| DC_TC | 88.6 | 88.4 | 89.5 | 87.4 | 0.772 | |
| DC_PSSM | 88.4 | 87.8 | 87.6 | 88.3 | 0.769 | |
| DC_CTD | 88.0 | 87.4 | 87.3 | 87.8 | 0.761 | |
| CTD_PSSM | 87.0 | 86.8 | 87.5 | 86.2 | 0.740 | |
| AAC_TC | 86.6 | 86.1 | 86.2 | 86.0 | 0.732 | |
| TC_PSSM | 87.6 | 87.5 | 89.6 | 85.6 | 0.753 | |
| AAC_CTD | 87.5 | 87.4 | 88.1 | 87.1 | 0.752 | |
| AAC_DC | 88.4 | 88.1 | 88.6 | 87.7 | 0.767 | |
| AAC_PSSM | 88.0 | 88.1 | 88.6 | 87.6 | 0.760 | |
| CNN-RNN | AAC_TC_PSSM | 88.8 | 88.2 | 89.1 | 87.5 | 0.777 |
| (Dictionary) | AAC_TC_CTD | 88.6 | 87.9 | 87.7 | 88.4 | 0.771 |
| TC_CTD_PSSM | 88.4 | 88.1 | 88.2 | 88.2 | 0.768 | |
| AAC_CTD_PSSM | 87.7 | 87.2 | 87.0 | 87.7 | 0.754 | |
| AAC_DC_TC | 89.2 | 89.0 | 90.3 | 87.9 | 0.785 | |
| AAC_DC_PSSM | 88.1 | 87.4 | 86.6 | 88.4 | 0.761 | |
| DC_CTD_PSSM | 88.0 | 87.9 | 89.4 | 86.7 | 0.760 | |
| AAC_DC_CTD | 89.1 | 89.1 | 90.4 | 87.8 | 0.783 | |
| DC_TC_CTD | 90.0 | 89.6 | 89.0 | 90.5 | 0.800 | |
| DC_TC_PSSM | 89.1 | 89.0 | 88.7 | 89.4 | 0.782 | |
| AAC_DC_TC_PSSM | 89.0 | 89.1 | 90.2 | 88.2 | 0.780 | |
| AAC_DC_TC_CTD | 87.9 | 87.6 | 89.6 | 85.8 | 0.760 | |
| AAC_TC_CTD_PSSM | 89.0 | 88.5 | 90.6 | 86.7 | 0.780 | |
| DC_TC_CTD_PSSM | 89.4 | 89.4 | 91.3 | 87.6 | 0.789 | |
| AAC_DC_CTD_PSSM | 88.9 | 88.7 | 90.4 | 87.3 | 0.780 | |
| AAC_DC_TC_CTD_PSSM | 88.5 | 88.4 | 89.1 | 87.8 | 0.771 |