Table 1.

Amino acid sequences of Tk-hefu derivatives and their activity against K_V channels

^a Gray shading highlights cysteine residues that form disulfide bonds; amino acid substitutions introduced in Tk-AMP-X2 to attain Tk-hefu peptides are in bold.

^b -, no activity at 20 μM.

^cK_D values as reported in (19).

^d Empty box means that the activity was not tested.

^e “X/Y” means that at concentration of X nM, Y percent of block was observed.

^f X ± Y represent IC₅₀ values in nM.

^g These data represent EC₅₀ values in nM.