Table 3.
Comparison of known peptide toxins presenting selective activity to KV1.6
| Ligand | KV1.1 | KV1.2 | KV1.3 | KV1.6 | Reference |
|---|---|---|---|---|---|
| Tk-hefu-11 | 1000/41a | 1000/50 | 70b | 10b | This work |
| Scorpion toxins | |||||
| Kbot21 | 1000/100 | 1000/100 | 1000/100 | 76c | (10) |
| HelaTx1 | 9900b | 30,000/5 | 30,000/20 | 30,000/60 | (12) |
| Sea anemone toxins | |||||
| AbeTx1 | 672c | 167c | 3000/20 | 116c | (9) |
| κ-Actitoxin-Bcs3b | 14c | 80c | 13c | 8c | (8) |
| Conotoxins | |||||
| Conopeptide Y-Fe1 | d | >30,000 | >50,000 | 8800c | (11) |
| Conopeptide Y-Pl1 | 2000c | >50,000 | 170c | (11) | |
| α/κ-Conotoxin pl14a | >1000 | >1000 | >1000 | 1590c | (13) |
a
“X/Y” means that at concentration of X nM, Y percent of block was observed.
b
EC50 values in nM.
c
IC50 values in nM.
d
Empty box, no data.