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. 2022 Sep 30;298(11):102559. doi: 10.1016/j.jbc.2022.102559

Figure 1.

Figure 1

Pathways and enhancers that control the expression of Cyp27b1 and Cyp24a1 in the kidney.A, schematic diagram for the regulation of vitamin D metabolism and serum calcium and phosphate homeostasis in the kidney. Pathways either increase (+) or decrease (−) in response to changing calcium and phosphate levels. Our genetic models (black) and previously existing models (gray) are overlaid on or near the pathways they disrupt. Schematic representation of PTH, FGF23, and 1,25(OH)2D3 actions on Cyp27b1 (B) and Cyp24a1 (C) through tissue-specific enhancers M1 and M21, which control Cyp27b1 as well as DS1 (-21 kb to -32 kb) and DS2 (-35 kb to -37 kb) enhancers that control Cyp24a1. Figures adapted from recent studies (2, 15). DS, DownStream region of Cyp24a1; FGF23, fibroblast growth factor 23; 1,25(OH)2D3, 1,25-dihydroxyvitamin D3; PTH, parathyroid hormone.